La Dra. Allison Astuya es investigadora de la línea 5 de COPAS Sur-Austral y actualmente es profesor asociado de la Facultad de Ciencias Naturales y Oceanográficas de la Universidad de Concepción.
Correo: aastuya@udec.cl
Teléfono: 56(41)-2207107
Área de especialización
Biotecnología Marina, Toxicología y Toxinas Marinas, Bioensayos Celulares.
Líneas de investigación
Cultivo de células de organismos acuáticos, Toxicología in Vitro, modelos in Vitro para detección de toxinas marinas e ictiotoxicidad, moléculas naturales de origen marino con potencial uso biomédico.
Antecedentes académicos
| 2006 | Doctor en Ciencias Biológicas, área Biología Celular y Molecular, Universidad de Concepción, Chile. |
| 1998 | Bioquímica, Universidad Católica de Valparaíso, Chile. |
Miembro de comités y consejos/otras afiliaciones
2014 a la fecha – Experto Grupo de Estudio “Toxinas Marinas” para la Asociación Chilena para la inocuidad alimentaria ACHIPIA.
2008 a la fecha – Consejo de la carrera IBMA. Participación en el consejo de carrera IBMA, de la Facultad de Cs. Naturales y Oceanográficas, Universidad de Concepción.
Premios y distinciones
Ciencia con Impacto 2018 _VDRI.
Asignación Académica (Rect. Nº050-2013).Universidad de Concepción (Enero 2013 – Diciembre 2015).
Adjudicación concurso Patentamiento 2014 (VDRI Nº783/14).
Number of publications: 28
Publicaciones
| Name | Autores | Palabras clave | Año |
|---|---|---|---|
| In vitro evaluation of the potential allelopathic and ichthyotoxic effect of the raphidophyte Heterosigma akashiwo and the dinoflagellate Alexandrium catenella | Allisson Astuya-Villalón, Bárbara López, Verónica Avello, Alejandra Rivera, Ambbar Aballay-González, Viviana Ulloa, Alejandra Aguilera-Belmonte, Juan José Gallardo Rodríguez | Ichthyotoxicity, Bloom-forming microalgae, Allelopathy, in vitro Bioassay | 2022 |
| Physiological Response of Atlantic Salmon (Salmo salar) to Long-Term Exposure to an Anesthetic Obtained from Heterosigma akashiwo | Ana Teresa Gonçalves, Alejandra Llanos-Rivera, Miguel Ruano, Veronica Avello, Juan José Gallardo-Rodriguez, Allisson Astuya-Villalón | natural anesthetic, welfare practices, Atlantic salmon (Salmo salar), physiological response | 2022 |
| Salmonid MyD88 is a key adapter protein that activates innate effector mechanisms through the TLR5M/TLR5S signaling pathway and protects against Piscirickettsia salmonis infection | Carolina Muñoz-Flores, Allisson Astuya-Villalón, Alex Romero, Jannel Acosta, Jorge R. Toledo | Toll-like receptor 5 MyD88, Salmonids, Reactive oxygen species, Piscirickettsia salmonis, Flagellin | 2022 |
| Search for potential biomarkers for saxitoxin detection. | Alejandra A.Rivera, Ambbar Aballay-González, Ana Teresa Gonçalves, Estefanía Tarifeño, Viviana Ulloa, Juan José Gallardo, Allisson Astuya-Villalón | Neuro-2a cell-based assay, Molecular biomarker, Shellfish, PSP | 2021 |
| Production of extracts with anaesthetic activity from the culture of Heterosigma akashiwo in pilot-scale photobioreactors | Gallardo-Rodríguez, J. J., Astuya-Villalón, A., Avello, V., Llanos-Rivera, A., Krock, B., Agurto-Munoz, C., Sanchez-Miron, A., Garcia-Camacho, F. | Raphidophytes, Anaesthetic, Bioprocess, Photobioreactor | 2020 |
| Antiproliferative activity of carotenoid pigments produced by extremophile bacteria. | Cristian Tapia, Bárbara Lopez, Allisson Astuya, José Becerra, Concetta Gugliandolo, Boris Parra and Miguel Martínez | Arthrobacter sp., decaprenoxanthin, Deinococcus sp., deinoxanthin, extremophiles | 2019 |
| Neuro-2a cell-based assay for toxicity equivalency factor – proposal and evaluation in Chilean contaminated shellfish samples. | Ambbar Aballay-González, Juan José Gallardo-Rodriguez, Macarena Silva-Higuera, Alejandra Rivera, Viviana Ulloa, Lorena Delgado-Rivera, Andrea Rivera-Belmar, Allisson Astuya | Neuro-2a cell-based assay, Toxicity equivalency factor, Shellfish, PSP | 2019 |
| Talaromyces australis and Penicillium murcianum pigment production in optimized liquid cultures and evaluation of their cytotoxicity in textile applications. | Vicente A. Hernández, Ángela Machuca, Isaac Saavedra, Daniel Chávez, Allisson Astuya, Carolina Barriga | Fungal pigments, IC50, Mammalian cell lines, Natural pigments, Response surface methodology, Wool fabrics | 2019 |
| Polyphenols obtained from Didymosphenia geminata (Lyngbye) Schmith altered the viability and proliferation of salmonids cells lines SHK-1 and CHSE-214 | Olivares-Ferretti P., Hernandez K., Peredo-Parada M., Chávez V., Carmona E., Astuya A., Parodi J. | Didymo, Especies Invasoras, Patagonia, Viabilidad, Toxicidad | 2019 |
| In vitro immunomodulatory activities of peptides derived from Salmo salar NK-lysin and cathelicidin in fish cells | Acosta J., Roaa F., González-Chavarría I., Astuya A., Maura R., Montesino R., Muñoz C., Camacho F., Saavedra P., Valenzuela A., Sánchez O., Toledo J.R. | Antimicrobial peptide, NK-Lysin, Cathelicidin, Immune system, Salmo salar | 2019 |
| Salinity-Growth Response and Ichthyotoxic Potency of the Chilean Pseudochattonella verruculosa. | Mardones J.I., Fuenzalida G., Zenteno K., Alves-de-Souza C., Astuya A., Dorantes-Aranda J.J. | Antimicrobial peptide, NK-Lysin, Cathelicidin, Immune system, Salmo salar | 2019 |
| Study of the ichthyotoxic microalga Heterosigma akashiwo by transcriptional activation of sublethal marker Hsp70b in Transwell co-culture assays. | Astuya A., Rivera A., Vega-Drake K., Aburto C., Cruzat F., Ulloa V., Caprile T., Gallardo-Rodríguez J.J. | N/A | 2018 |
| Activation of membrane-bound and soluble Toll-like Receptors 5 in Salmo salar depends on the MyD88 signalling pathway. | Muñoz-Flores C., Astuya A., Roa F.J., Romero A., Acosta J., Sánchez O., Toledo J.R | N/A | 2018 |
| A critical review on control methods for harmful algal blooms. | Gallardo‐Rodríguez J.J., Astuya‐Villalón A., Llanos‐Rivera A., Avello‐Fontalba V., Ulloa‐Jofré V. | Algicides, Clays, Control, Flocculation, Harmful algal blooms | 2018 |
| Steroidal composition and cytotoxic activity from fruiting body of Cortinarius xiphidipus. | Torres S., Cajas D., Palfner G., Astuya A., Aballay A., Pérez C., Hernández V., Becerra J. | Cortinarius xiphidipus , Mycorrhizal fungus, Fruiting body, Ergosterols, Cytotoxicity | 2017 |
| Fish Nutrition Additives in SHK-1 Cells: Protective Effects of Silymarin. | Sánchez R., Olivares P., Carmona E., Astuya A., Herrera H., Parodi J. | Fish, Nutrition, Silymarin, Cell Cultures | 2016 |
| In vitro modulation of Drimys winteri bark extract and the active compound polygodial on Salmo salar immune genes after exposure to Saprolegnia parasitica. | Pereira-Torres D., Gonçalves A.T., Ulloa V., Martínez R., Carrasco H., Olea A.F., Espinoza L., Gallardo-Escárate C.,Astuya A. | D. winteri, S. parasitica, Saprolegniosis, Polygodial, Immunostimulant, In vitro, Gene expression | 2016 |
| Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes. | García-Krauss A., Ferrada L., Astuya A., Salazar K., Cisternas P., Martínez F., Ramírez E., Nualart F. | Ascorbic acid, Dehydroascorbic acid, Neuron, Astrocyte, Cell death, Recycling, Oxidative stress | 2016 |
| Antioxidant and anti-inflammatory activities of Pinus radiata bark extract in salmonid cell lines. | Astuya A., Ziehe J., Rivera A., Ortiz S., Ulloa V., Roeckel M., Asp E., Fernández K. | Pinus radiata, Bark extract, Antioxidant, Anti-inflammatory, Salmon cell lines | 2016 |
| Matrix effects on a cell-based assay used for the detection of paralytic shellfish toxins in bivalve shellfish samples. | Aballay-González A., Ulloa V., Rivera A., Hernández V., Silva M., Caprile T., Delgado-Rivera L., Astuya A. | Cell-based assay, Paralytic shellfish toxins, Matrix effect | 2016 |
| Neurotoxin-like compounds from the ichthyotoxic red tide alga Heterosigma akashiwo induce a TTX-like synaptic silencing in mammalian neurons. | Astuya A., Ramírez A.E., Aballay A., Araya J., Silva J., Ulloa V., Fuentealba J. | Heterosigma akashiwo, Raphidophyte, Na-channel blockers, TTX-like compounds, Harmful algal bloom, Synaptic silencing | 2015 |
| Saxitoxin Modulates Immunological Parameters and Gene Transcription in Mytilus chilensis Hemocytes. | Astuya A., Carrera C., Ulloa V., Aballay A., Núñez-Acuña G., Hégaret H., Gallardo-Escárate C. | Saxitoxin, Hemocytes, Immune response, Paralytic shellfish poisoning, Reactive oxygen species (ROS) | 2015 |
| Complementary expression of EphA7 and SCO-spondin during posterior commissure development. | Stanic K., Vera A., González M., Recabal A., Astuya A., Torrejón M., Montecinos H., Caprile T. | EphA7, Posterior commissure, SCO-spondin, Axon guidance, Subcommissural organ, Chick embryo, Prosomere 1 | 2014 |
| Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis. | Sottorff I., Aballay A., Hernández V., Roa L., Muñoz L.X., Silva M., Becerra J., Astuya A. | Holothuria, Holothurinoside D, Saponins | 2013 |
| In vitro evaluation of immunomodulatory activity of total extracts of Canelo (Drimys winteri) and active compound polygodial in salmon head kidney cells. | Pereira D., Carrasco H., Astuya A. | N/A | 2013 |
| Transcriptional responses of Mytilus chilensis exposed in vivo to saxitoxin (STX). | Núñez-Acuña G., Aballay A. E., Hégaret H., Astuya A.P., Gallardo-Escárate C. | N/A | 2013 |
| ISA virus outside the cage: Ichthyofauna and other possible reservoirs to be considered for marine biosafety management in the far-southern ecosystems of Chile. | González R.R., Ruiz P., Llanos-Rivera A., Cruzat F., Silva J., Astuya A., Grandón M., Jara D., Aburto C. | Ichthyo, fauna, Environmental reservoir, Epizooty, Salmo salar, HPR | 2011 |
| The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids. | Caprile T., Salazar K., Astuya A., Cisternas P., Silva-Alvarez C., Montecinos H., Millán C., García M., Nualart F. | Brain cortex, Flavonoid, Neuron, Sodium–vitamin C co-transporters 2, Stem cells | 2009 |
